Syllabus:  Neurology and Neurological Sciences 220
Computational Neuroscience
Spring Quarter 2013
http://nens220.stanford.edu

Week

Tuesday (lecture)

Thursday (Discussion)

Problem Set / Paper / Reading

 

April 2

April 4

 

1

LECTURE: Introduction / Neuroelectronics I

LECTURE: NEURON tutorial

bistable.hoc nap.mod pasnak.mod


Koch Chapter 1

 

April 9

April 11

 

2

Neuroelectronics Part II

NEURON Tutorial, part two, advanced features and mod files

PS #1: input output relations in neurons

Koch Chapter 6

 

April 16

April 18

 

3

No Lecture

Paper 1: Active propagation of somatic action potentials into neocortical pyramidal cell dendrites (Stuart & Sakman)

PS #2: Mechanisms of active propagation
 Koch Chapters 2 and 3

Bush & Sejnowski, 1993

 

April 23

April 25

 

4

 

Propagation of signals within neurons, axonal and dendritic  mechanisms

 

Paper 2: Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential . (Shu et al.)
Combined analog and action potential coding in hippocampal mossy fibers  (Alle et al.)

PS#3: Analog/digital axonal transmission
Koch Chapter 4

 

April 30

May 2

 

5

Hodgkin Huxley Analysis of spike generation

 

Paper 3: Dynamic spike threshold reveals a mechanism for synaptic coincidence detection in cortical neurons in vivo (Azouz and Grey). See also Azouz and Grey, 2003

Koch Chapter 9  

 

May 7

May 9

 

6

Beyond Hodgkin-Huxley & dynamical systems

Paper 4: The 'window' component of the low threshold Ca2+ current produces input signal amplification and bistability in cat and rat thalamocortical neurone  (Williams et al., 1997)

PS #4: Coincidence Detection
Koch Chapter 11

 

May 14

May 16

 

7

Neuronal Communication 

Paper 5: A mechanism for generation of long-range synchronous fast oscillations in the cortex (Bartos & Jonas) Traub model

PS #5: Network synchrony driven by inhibition
Final Project proposal due

 

May 21

May 23

 

8

Plasticity and Homeostasis

Paper 6: Axonal delay lines for time measurement in the owl's brainstem  (Konishi and Carr)

PS #6: Gain Control
Koch Chapter 16

 

May 28

May 30

 

9

Realistic Neuronal Networks, Oscillations, resonance, synchrony

Paper 7: Detection of synchrony in the activity of auditory nerve fibers by octopus cells of the mammalian cochlear nucleus (Oertel)

Koch Chapter 13

 

June 4

June 6, Alway M112

 

10

Gain control

Paper 8: Gain Control Abbott et al 1997 For background, please also read Varela et al 1997

 

 

June 11

June 13

 

11

Final Presentations

Final Presentations